What is oregano oil good for
Oregano (Origanum vulgare) is a perennial herb with olive-green leaves and purple flowers, native to temperate Western and Southwestern Eurasia and the Mediterranean region. Turkey is one of the largest exporters of oregano. It now grows on most continents and under a variety of conditions. Countries known for producing high-quality oregano essential oils include Greece, Israel, and Turkey. Oregano grows 1-3 feet tall and is closely related to mint, thyme, marjoram, basil, sage, and lavender, with opposite leaves 1–4 cm (0.39–1.57 in) long. The flowers are purple, 3–4 mm (0.12–0.16 in) long, produced in erect spikes. It is sometimes called wild marjoram, and its close relative, O. majorana, is known as sweet marjoram. Outside of the U.S. and Europe, plants referred to as “oregano” may be other species of Origanum, or other members of the Lamiaceae family.
Oregano oil and oregano have been used in folk medicine since ancient times 1. Oregano essential oil is extracted from the leaves of the oregano plant. Some people take oregano by mouth for respiratory tract disorders such as coughs, asthma, allergies, croup, and bronchitis. Oregano is also taken by mouth for stomach disorders such as heartburn, bloating, and parasites. It is also taken by mouth for painful menstrual cramps, rheumatoid arthritis, urinary tract disorders including urinary tract infections (UTIs), headaches, diabetes, bleeding after having a tooth pulled, heart conditions, and high cholesterol. Although oregano or its oil may be used as a dietary supplement, there is no clinical evidence to indicate that either has any effect on human health 2.
Proponents of oil of oregano claim it can treat a variety of illnesses, including sinus disorders. Like many spices, oregano does have some antibacterial and antifungal properties — making it at least plausible that it might help or prevent some sinus problems caused by bacteria and fungi.
Oregano oil is applied to the skin for skin conditions including acne, athlete’s foot, dandruff, canker sores, warts, wounds, ringworm, rosacea, and psoriasis; as well as for insect and spider bites, gum disease, toothaches, muscle and joint pain, and varicose veins. Oregano oil is also applied to the skin as an insect repellent.
Unfortunately, there have been no published human trials that have looked at oregano oil specifically for this use. For this reason, it isn’t known what role, if any, oil of oregano plays in treating or preventing sinusitis.
In 2005, the US Federal Trade Commission brought legal action against a firm that had claimed oregano oil treated colds and flu or relieved bacterial and viral infections 3. In 2014, the US Food and Drug Administration warned a Utah company, Young Living, that its herbal products, including oregano essential oil, were being promoted to have numerous anti-disease effects and so were being sold as unauthorized misbranded drugs subject to seizure and federal penalties 4.
In the foods and beverages industry, oregano and oregano oil are used as a culinary spice, flavoring and food preservative.
Figure 1. Oregano
Oregano oil and candida (test tube studies)
Oregano has antioxidant properties and exhibits antimicrobial activity against bacteria and fungi 5, 6. The effects of oregano essential oil on yeasts of medical importance such as Candida albicans isolated from human patients have also been studied 7. Some studies suggest that oregano exerts a therapeutic effect when administered to rats experimentally infected with Trichophyton rubrum 5. The antifungal activity of oregano essential oil against some species of Aspergillus such as A. parasiticus , A. niger , A. flavus and A. ochraceus was demonstrated in studies where it was shown to inhibit growth and aflatoxin production 8. In animal and test tube studies, Aligiannis et al . 9 evaluated the Minimal Inhibitory Concentration (MIC) of the essential oils of two species of Oregano and found values between 0.28 and 1.27 mg per mL for bacteria and from 0.65 to 1.27 mg per mL for fungi, which are similar to the values found in another study 10.
Chromatographic analysis of oregano essential oil revealed the presence of 4-terpineol, γ-terpinene, thymol and carvacrol [2-methyl-5-(1-methylethyl)phenol] 11 among its main constituents. They possess multiple biological properties such as anti-inflammatory, anti-leishmanial, antioxidant, hepatoprotective and anti-tumoral activities 12, 13. The concentration of phenolic monoterpenes was high as compared to those of the other compounds present in the oil (see Table 1). Some monoterpenes and sesquiterpenes could be responsible for the susceptibility of the fungal isolates tested to this essential oil, since the antifungal activity of oregano oil has been attributed to thymol, carvacrol and eugenol 14.
According to some studies, the composition, quality and content of essential oils present in plants are subject to great variation and are influenced by diverse factors such as the geographical and climatic conditions as well as the conditions used for culture, drying and storage 15.
Inhibition of microorganisms by essential oils seems to rely on different mechanisms of action 16. Toxic effects on membrane structure and function have been generally used to explain the antimicrobial action of essential oils and their monoterpenoid compounds 17.
Some studies suggest that the antimicrobial action of essential oils can be a consequence of a negative effect on enzymes, including those involved in the production of energy and synthesis of structural components of the microorganism, in addition to destruction or inactivation of genetic material 18.
Phenolic compounds present in essential oils may disturb membrane-embedded proteins and inhibit cellular respiration. Also, alterations in the ion transport processes of the cell membrane and modifications in the activity of calcium channels can cause an increase in cell permeability and consequent release of vital intracellular constituents 18.
Our conclusion: Despite positive results in test tube studies, there is currently no human study that could prove the anti-candida (antifungal) effect of oregano essential oil, we therefore put these test results as inconclusive and not recommended for clinical use. More research would be needed to confirm these test tube findings.
Table 1. Compounds identified in Oregano essential oil using chromatographic analysis
|Peak||Retention time (min)||Compounds||MF||C*(%)|
|13||18.49||trans sabinene hidrate||C10H18O||0.07|
|15||20.58||cis sabinene hidrate||C10H18O||0.08|
|23||30.27||methyl thymol eter||C11H16O||0.10|
|24||30.89||methyl carvacrol eter||C10H18O||0.71|
Oregano oil and Staph infection (test tube studies)
Staphylococci are important pathogens. Eradication of these micro-organisms is not always successful due to their ability to form biofilms. Experimental evidence has shown that micro-organisms in biofilms are less susceptible to conventional treatment 20 than their planktonic counterparts. Many factors contribute to the lowered susceptibility of bacteria enclosed in a biofilm, and include the induction of a biofilm phenotype, the stress response and failure of the antimicrobial agents to penetrate the biofilm 21. Recently, there has been considerable interest in the study of plant materials as sources of new compounds for processing into therapeutic agents. One approach may be the use of oregano essential oils that have been shown to be potential agents in the treatment of infections, and are safe in terms of human and animal health. In this context, oregano oil and its major phenolic components, carvacrol [2-methyl-5-(1-methylethyl)phenol] and thymol [2-isopropyl-5-methylphenol], are known for their wide spectrum of antimicrobial activity, which has been the subject of several investigations in test tubes 11 and in animals 22. In a test tube study scientists have shown that oregano essential oils inhibited growth of preformed biofilm and interfered with biofilm formation during planktonic growth of Staph bacteria. The antimicrobial activity of oregano oil is mostly attributed to the action of its principal phenolic components, carvacrol [2-methyl-5-(1-methylethyl)phenol] and thymol [2-isopropyl-5-methylphenol], which exhibit significant bactericidal activity when tested separately 23. Due to their hydrophobic nature, carvacrol and thymol interact with the lipid bilayer of cytoplasmic membranes causing loss of integrity and leakage of cellular material such as ions, ATP and nucleic acid 24. Hence, carvacrol and thymol, alone or in oregano oil, could diffuse through the polysaccharide matrix of the biofilm and destabilize it due to their strong intrinsic antimicrobial properties. This hypothesis is supported by the anti-plaque effects of a thymol-based mouthwash, in part attributable to rapid-kill and plaque-permeating abilities 25.
Table 2. Comparative analysis of antimicrobial and anti-biofilm potential of thymol, carvacrol and citral against biofilm forming micro-organisms
|MicroOrganisms (Strain)||Essential Oil Active Components (μg/ml)|
|Stapylococcus aureus (6MEa, ATCC 6538b)||300a||600a||2,500a||100a||600a||2,500a||500b||500b||1,000b||26|
|Stapylococcus epidermidis (ATCC 35984)||600||1,250||5,000||300||1,250||5,000||-||-||26|
|Klebsiella pneumoniae (OXA-48)||200||200||-||125||125||-||-||-||-||27|
|Pseudomonas aeruginosa (GIM)||800||800||-||250||500||-||-||-||-||27|
|Acetinobacter baumanni (SIM)||200||400||-||62||250||-||-||-||-||27|
|Candida albicans (ATCC 66396d, 04d)||100c||-||300c||97.6c||-||292.8c||148.62d||-||594d||28|
|Candida glabrata (IHEM 9556e, ATCC 2001f)||200e||-||1,250e||195.2e||-||1,250e||128f||-||-||28|
|Candida parapsilosis (ATCC 22019)||200||-||600||195.2||-||1,250||500||-||5,000||28|
|Cryptococcus neoformans (NCIM 3541)||16||32||128||32||64||256||64||128||256||29|
|Cryptococcus laurentii (NCIM 3373)||8||16||64||16||32||128||32||64||256||29|
Carvacrol and thymol may also be responsible for the effects observed on biofilm formation. Knowles et al. 31 suggested that continued exposure of Staph aureus to non-biocidal concentrations of carvacrol disrupted normal development of dual-species biofilm, preventing the build up of protein mass, arresting at the microcolony stage. Alternatively, the oils could interact with surface proteins, leading to an alteration of the bacterial cell surface and in part compromising the initial attachment phase to polystyrene microtitre plates. In this context, Juven et al. 32 suggested a reaction between phenolic compounds (such as thymol) and bacterial membrane proteins.
The findings of the present test tube study highlight the promising role of oregano, carvacrol and thymol as new lead structures in the search for novel antibacterial agents. Data in the literature on the availability and pharmacokinetics of carvacrol and thymol 33 and on acute and short-term in vivo effects, suggest that they may not pose a risk for human and animal health 34. Moreover, both carvacrol and thymol have been classified as GRAS (generally recognized as safe) and their use in food has been approved by European Parliament and Council for the food industry uses primarily for flavoring and aromatizing foods 35 making them a potential option for developing anti-microbial drugs. Therefore, further experiments are needed substantiate these findings and support their use in human clinical trials as anti-bacterial and anti-fungal.
How effective is oregano oil ?
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
The effectiveness ratings for oregano are as follows 36:
Insufficient evidence to rate effectiveness for:
- Parasites in the intestines. Some early research shows that taking 200 mg of a specific oregano leaf oil product (ADP, Biotics Research Corporation, Rosenberg, Texas) by mouth three times daily with meals for 6 weeks can kill certain types of parasites; however, these parasites usually do not require medical treatment.
- Wound healing. Early research suggests that applying an oregano extract to the skin twice daily for up to 14 days after a minor skin surgery might reduce the risk of infection and improve scars.
- Athlete’s foot.
- Bleeding disorders.
- Oil of oregano for colds
- Heart conditions.
- High cholesterol.
- Indigestion and bloating.
- Muscle and joint pain.
- Painful menstrual periods.
- Urinary tract infections (UTI).
- Varicose veins.
- Other conditions.
More evidence is needed to rate oregano for these uses.
Oregano oil side effects
Oregano leaf and oregano oil are LIKELY SAFE when taken in amounts commonly found in food. Oregano leaf is POSSIBLY SAFE when taken by mouth or applied to the skin appropriately as medicine. Mild side effects include stomach upset. Oregano might also cause an allergic reaction in people who have an allergy to plants in the Lamiaceae family. Oregano oil should not be applied to the skin in concentrations greater than 1% as this might cause irritation.
Special precautions and warnings
Pregnancy and breast-feeding: Oregano is POSSIBLY UNSAFE when taken by mouth in medicinal amounts during pregnancy. There is concern that taking oregano in amounts larger than food amounts might cause miscarriage. There is not enough reliable information about the safety of taking oregano if you are breast feeding. Stay on the safe side and avoid use.
Bleeding disorders: Oregano might increase the risk of bleeding in people with bleeding disorders.
Allergies: Oregano can cause reactions in people allergic to Lamiaceae family plants, including basil, hyssop, lavender, marjoram, mint, and sage.
Diabetes: Oregano might lower blood sugar levels. People with diabetes should use oregano cautiously.
Surgery: Oregano might increase the risk of bleeding. People who use oregano should stop 2 weeks before surgery.
Are there interactions with medications ?
Moderate – Be cautious with this combination.
- Medications for diabetes (Antidiabetes drugs)
Oregano might decrease blood sugar. Diabetes medications are used to lower blood sugar. In theory, taking some medications for diabetes along with oregano might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others..
- Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Oregano might slow blood clotting. In theory, taking oregano along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), dabigatran (Pradaxa), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others..
Are there interactions with herbs and supplements ?
Oregano might interfere with copper absorption. Using oregano along with copper might decrease the absorption of copper.
- Herbs and supplements that can lower blood sugar
Oregano might lower blood sugar. In theory, taking oregano along with herbs and supplements that also lower blood sugar might reduce blood sugar levels too much. Some herbs and supplements that might lower blood sugar include alpha-lipoic acid, bitter melon, chromium, devil’s claw, fenugreek, garlic, guar gum, horse chestnut, Panax ginseng, psyllium, Siberian ginseng, and others.
- Herbs and supplements that might slow blood clotting
Using oregano along with herbs that can slow blood clotting might increase the risk of bleeding in some people. These herbs include angelica, clove, danshen, garlic, ginger, ginkgo, Panax ginseng, horse chestnut, red clover, turmeric, and others.
Oregano might interfere with iron absorption. Using oregano along with iron might decrease the absorption of iron.
Oregano might interfere with zinc absorption. Using oregano along with zinc might decrease the absorption of zinc.
Are there interactions with foods ?
There are no known interactions with foods.
What dose is used ?
The appropriate dose of oregano depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for oregano (in children/in adults). Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.References
- Oregano. Medline Plus. https://medlineplus.gov/druginfo/natural/644.html
- FTC Targets Bogus Anti-Aging Claims for Pills and Sprays Promising Human Growth Hormone Benefits. https://www.ftc.gov/news-events/press-releases/2005/06/ftc-targets-bogus-anti-aging-claims-pills-and-sprays-promising
- Adam K., Sivropoulou A., Kokkini S., Lanaras T., Arsenakis M. Antifungal activities of Origanum vulgare subsp. Hirusutum , Menthab spicata , Lavanula angustifólia and salvia fruticosa essential oils against human pathogenic fungi. J. Agricul Food Chem. 1998;46:1739–1745.
- Milos M., Mastelic J., Jerkovic I. Chemical composition and antioxidant effect of glycosidically bound volatile compounds from oregano (Origanum vulgare L. spp. hirtum) Food Chem. 2000;71:79–83.
- Chami N., Chami F., Bennis S., Trouillas J., Remmal A. Antifungal treatment with carvacrol and eugenol of oral candidiasis in immunosuppressd rats. The Braz. J. Infec. Dis. 2004;8(3):217–226. https://www.ncbi.nlm.nih.gov/pubmed/15476054
- Basilico M.Z., Basilico J.C. Inhibitory effects of some spice essential oils on Aspergillus ochraceus NRRL 3174 growth and achratoxin A production. Lett. Appl. Microbiol. 1999;29:238–241. https://www.ncbi.nlm.nih.gov/pubmed/10583751
- Composition and antimicrobial activity of the essential oils of two Origanum species. Aligiannis N, Kalpoutzakis E, Mitaku S, Chinou IB. J Agric Food Chem. 2001 Sep; 49(9):4168-70. https://www.ncbi.nlm.nih.gov/pubmed/11559104/
- Manohar V, Ingram C., Gray J. Talpur N.A. Bagghi D., Preuss H.G. Antifungal activities of Origanum oil against Candida albicans. Molec. Cel. Bioch. 2001;228:111–117. https://www.ncbi.nlm.nih.gov/pubmed/11855736
- Lambert, R. J. W., Skandamis, P. N., Coote, P. J. & Nychas, G. J. E. ( 2001 ). A study of the minimum inhibitory concentration and mode of action of oregano essential oil, thymol and carvacrol. J Appl Microbiol 91, 453–462.
- Robledo, S., Osorio, E., Munoz, D., Jaramillo, L. M., Restrepo, A., Arango, G. & Velez, I. ( 2005 ). In vitro and in vivo cytotoxicities and antileishmanial activities of thymol and hemisynthetic derivatives. Antimicrob Agents Chemother 49, 1652–1655.
- Skold, K., Twetman, S., Hallgren, A., Yucel-Lindberg, T. & Modeer, T. ( 1998 ). Effect of a chlorhexidine/thymol-containing varnish on prostaglandin E2 levels in gingival crevicular fluid. Eur J Oral Sci 106, 571–575.
- Biological relevance of terpenoids. Overview focusing on mono-, di- and tetraterpenes. Wagner KH, Elmadfa I. Ann Nutr Metab. 2003; 47(3-4):95-106. https://www.karger.com/Article/Abstract/70030
- Kokkini S., Karousou R., Vokou D. Pattern of geographic variation of Origanum vulgare trichomes and essential oil content in Greece. Bioch System Ecol. 1994;22:517–528.
- Mechanisms of antibacterial action of three monoterpenes. Trombetta D, Castelli F, Sarpietro MG, Venuti V, Cristani M, Daniele C, Saija A, Mazzanti G, Bisignano G. Antimicrob Agents Chemother. 2005 Jun; 49(6):2474-8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1140516/
- Interactions of cyclic hydrocarbons with biological membranes. Sikkema J, de Bont JA, Poolman B. J Biol Chem. 1994 Mar 18; 269(11):8022-8.
- Mechanisms of antibacterial action of three monoterpenes. Trombetta D, Castelli F, Sarpietro MG, Venuti V, Cristani M, Daniele C, Saija A, Mazzanti G, Bisignano G. Antimicrob Agents Chemother. 2005 Jun; 49(6):2474-8.
- Cleff MB, Meinerz AR, Xavier M, et al. In vitro activity of origanum vulgare essential oil against candida species. Brazilian Journal of Microbiology. 2010;41(1):116-123. doi:10.1590/S1517-838220100001000018. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768597/
- Brown, M. R. W. & Gilbert, P. ( 1993 ). Sensitivity of biofilms to antimicrobial agents. J Appl Bacteriol 74, 87S–97S.
- Mah, T.-F. C. & O’Toole, G. A. ( 2001 ). Mechanisms of biofilm resistance to antimicrobial agents. Trends Microbiol 9, 34–39.
- Manohar, V., Ingram, C., Gray, J., Talpur, N. A., Echard, B. W., Bagchi, D. & Preuss, G. ( 2001 ). Antifungal activities of origanum oil against Candida albicans. Mol Cell Biochem 228, 111–117.
- Friedman, M., Henika, P. R. & Mandrell, R. E. ( 2002 ). Bactericidal activities of plant essential oils and some of their isolated constituents against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes, and Salmonella enterica. J Food Prot 65, 1545–1560.
- Trombetta, D., Castelli, F., Sarpietro, M. G., Venuti, V., Cristani, M., Daniele, C., Saija, A., Mozzanti, G. & Bisignano, G. ( 2005 ). Mechanisms of antibacterial action of three monoterpenes. Antimicrob Agents Chemother 49, 2474–2478.
- Ouhayoun, J. P. ( 2003 ). Penetrating the plaque biofilm: impact of essential oil mouthwash. J Clin Periodontol 30, (Suppl. 5), 10–12.
- Nostro A., Roccaro A. S., Bisignano G., Marino A., Cannatelli M. A., Pizzimenti F. C., et al. . (2007). Effects of oregano, carvacrol and thymol on Staphylococcus aureus and Staphylococcus epidermidis biofilms. J. Med. Microbiol. 56, 519–523. 10.1099/jmm.0.46804-0. https://www.ncbi.nlm.nih.gov/pubmed/17374894
- Raei P., Pourlak T., Memar M. Y., Alizadeh N., Aghamali M., Zeinalzadeh E., et al. . (2017). Thymol and carvacrol strongly inhibit biofilm formation and growth of carbapenemase-producing Gram negative bacilli. Cell. Mol. Biol. 63, 108–112. 10.14715/cmb/2017.63.5.20. https://www.ncbi.nlm.nih.gov/pubmed/28719354
- Dalleau S., Cateau E., Berges T., Berjeaud J. M., Imbert C. (2008). In vitro activity of terpenes against Candida biofilms. Int. J. Antimicrob. Agents 31, 572–576. 10.1016/j.ijantimicag.2008.01.028. https://www.ncbi.nlm.nih.gov/pubmed/18440786
- Kumari P, Mishra R, Arora N, et al. Antifungal and Anti-Biofilm Activity of Essential Oil Active Components against Cryptococcus neoformans and Cryptococcus laurentii. Frontiers in Microbiology. 2017;8:2161. doi:10.3389/fmicb.2017.02161. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681911/
- Cytotoxic Activity of Origanum Vulgare L. on Hepatocellular Carcinoma cell Line HepG2 and Evaluation of its Biological Activity. Elshafie HS, Armentano MF, Carmosino M, Bufo SA, De Feo V, Camele I. Molecules. 2017 Aug 30; 22(9). https://www.ncbi.nlm.nih.gov/pubmed/28867805/
- Knowles, J. R., Roller, S., Murray, D. B. & Naidu, A. S. ( 2005 ). Antimicrobial action of carvacrol at different stages of dual-species biofilm development by Staphylococcus aureus and Salmonella enterica serovar Typhimurium. Appl Environ Microbiol 71, 797–803.
- Juven, B. J., Kanner, J., Schved, F. & Weisslowicz, H. (1994). Factors that interact with the antibacterial action of thyme essential oil and its active constituents. J Appl Bacteriol 76, 626–631.
- De Vincenzi, M., Stammati, A., De Vincenzi, A. & Silano, M. ( 2004 ). Constituents of aromatic plants: carvacrol. Fitoterapia 75, 801–804.
- Chami, N., Bennis, S., Chami, F., Aboussekhra, A. & Remmal, A. ( 2005 ). Study of anticandidal activity of carvacrol and eugenol in vitro and in vivo. Oral Microbiol Immunol 20, 106–111.
- Essential oils in food preservation: mode of action, synergies, and interactions with food matrix components. Hyldgaard M, Mygind T, Meyer RL. Front Microbiol. 2012; 3():12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265747/