delayed pressure urticaria

What is pressure urticaria

Pressure urticaria also called delayed pressure urticaria or angioedema, is a form of chronic inducible urticaria characterized by the appearance of weals and/or angioedema after pressure to the skin. Pressure urticaria symptoms may occur immediately at sites of sustained pressure such as over areas of tight clothing or on the buttocks after sitting or more commonly, in delayed pressure urticaria, after a delay of 4–6 hours and last between 12 and 72 hours.

Pressure urticaria can be induced by a variety of stimuli including standing, walking, wearing tight clothes or sitting on a hard surface. Pressure urticaria can occasionally be aggravated by heat, aspirin or menstruation.

Pressure urticaria is uncommon but probably not rare. It is a chronic disease with a mean duration of 9 years. The peak age of onset is in the 20’s and 30’s.

Pressure urticaria causes

The cause of pressure urticaria is unclear but it is likely to be an autoimmune disease. Cells called mast cells are an important part in the process. Mast cells are tissue cells that contain chemicals, including histamine, which provoke wealing.

Pressure urticaria symptoms

The weal in pressure urticaria consists of redness and swelling of the skin and subcutaneous tissues. Lesions may last for 8–72 hours.

  • The hands, feet, trunk, buttocks, legs and face are most commonly affected.
  • Weals may be accompanied by fever, malaise, fatigue, and occasionally chills, headache and general joint aches.
  • Affected areas may be resistant to the development of new lesions for 1-2 days.
  • Up to 60% of patients with pressure urticaria also have chronic urticaria, immediate and/or delayed dermographism, and/or angioedema.

Pressure urticaria has a significant adverse impact on the quality of life of patients, with important limitations in everyday activities such as prolonged walking or standing. It can be disabling in patients who perform manual labor.

Pressure urticaria diagnosis

The diagnosis of delayed pressure urticaria is made clinically. It can be confirmed if a delayed weal occurs after a standardized pressure stimulus. This is often painful. In immediate pressure urticaria, a weal will appear within minutes of the stimulus.

A blood count may show an increased white cell count and ESR, but it is often normal.

A skin biopsy of delayed pressure urticaria shows inflammatory infiltrates which vary with the age of the weal. No vasculitis is found.

Pressure urticaria treatment

The results of treatment of pressure urticaria are relatively disappointing.

  • Reduce pressure stimuli as far as practicable.
  • Antihistamines help control associated chronic urticaria but rarely reduce pressure urticaria.
  • The ultrapotent topical corticosteroid clobetasol propionate may reduce inflammation. Skin thinning can result from regular use. Milder topical steroids are not of benefit.
  • Systemic corticosteroids produce variable responses and long-term use is associated with many potential adverse side effects.
  • Other possible therapies include nonsteroidal anti-inflammatory drugs (NSAIDs), colchicine, dapsone, sulfasalazine and montelukast.
  • Ciclosporin, methotrexate and intravenous gamma globulin have been used in a small number of patients with severe and refractory disease.
  • Tumor necrosis factor-alpha inhibitors have been reported of benefit in a few patients.