What are walnuts

A walnut is the nut of any tree of the genus Juglans (Family Juglandaceae). Walnuts are rounded, single-seeded stone fruits of the walnut tree commonly used for the meat after fully ripening. Following full ripening, the removal of the husk reveals the wrinkly walnut shell, which is usually commercially found in two segments (three-segment shells can also form). Technically a walnut is the seed of a drupe or drupaceous nut, and thus not a true botanical nut. There are two major varieties of walnuts grow in in the United States—the English or Persian walnut (Juglans regia) and the Black walnut (Juglans nigra). The English Walnut originated in Persia, and the Black walnut is native to the United States. The black walnut is of high flavor, but due to its hard shell and poor hulling characteristics it is not grown commercially for nut production. Numerous walnut cultivars have been developed commercially, which are nearly all hybrids of the English walnut ¹.

Other species include Juglans californica, the California black walnut (often used as a root stock for commercial breeding of English walnut), Juglans cinerea (butternuts), and Juglans major, the Arizona walnut. Walnuts are used for food after being processed while green for pickled walnuts or after full ripening for its nutmeat. Nutmeat of the eastern black walnut from the Juglans nigra is less commercially available, as are butternut nutmeats from Juglans cinerea.

Walnuts, like other tree nuts, must be processed and stored properly. Poor storage makes walnuts susceptible to insect and fungal mold infestations; the latter produces aflatoxin – a potent carcinogen. A mold-infested walnut batch should be entirely discarded ².

The ideal temperature for longest possible storage of walnuts is in the −3 to 0 °C (27 to 32 °F) and low humidity – for industrial and home storage. However, such refrigeration technologies are unavailable in developing countries where walnuts are produced in large quantities; there, walnuts are best stored below 25 °C (77 °F) and low humidity. Temperatures above 30 °C (86 °F), and humidities above 70 percent can lead to rapid and high spoilage losses. Above 75 percent humidity threshold, fungal molds that release dangerous aflatoxin can form ², ³.

Are walnuts good for you ?

Many people think of nuts as just another junk food snack. In reality, nuts are excellent sources of healthy fat, protein, and other healthful nutrients.

One surprising finding from nutrition research is that people who regularly eat nuts are less likely to have heart attacks or die from heart disease than those who rarely eat them ⁴. Several of the largest cohort studies, including the Adventist Study, the Iowa Women’s Health Study, the Nurses’ Health Study I (76,364 women from 1980 to 2012),  Nurses’ Health Study II (92,946 women from 1991 to 2013) and the Health Professionals Follow-Up Study (41,526 men from 1986 to 2012) have shown a consistent 30 percent to 50 percent lower risk of myocardial infarction (heart attack), sudden cardiac death or cardiovascular disease associated with eating nuts several times a week.

Total nut consumption was inversely associated with total cardiovascular disease and coronary heart disease after adjustment for cardiovascular risk factors ⁴. The pooled multivariable hazard ratios for cardiovascular disease were 0.86 (95% confidence interval) and coronary heart disease 0.80 (95% confidence interval) among participants who consumed 1 serving of nuts (28 g) 5 or more times per week, compared with the reference category (never or almost never). Consumption of peanuts and tree nuts (2 or more times/week) and walnuts (1 or more times/week) was associated with a 13% to 19% lower risk of total cardiovascular disease and 15% to 23% lower risk of coronary heart disease. In fact, the US Food and Drug Administration (FDA) now allows some nuts and foods made with them to carry this claim: “Supportive but not conclusive research shows that eating 1.5 ounces per day of walnuts, as part of a low saturated fat and low cholesterol diet and not resulting in increased caloric intake, may reduce the risk of coronary heart disease. See nutrition information for fat [and calorie] content” ⁵.

Figure 1. Nut Consumption and Risk of Cardiovascular Disease

Note: CVD = cardiovascular disease; CHD = coronary artery disease; Hazard Ratio = A measure of how often a particular event happens in one group compared to how often it happens in another group, over time. Anything under 1.0 is better. For example, a hazard ratio of 0.83 for stroke in those who consumes walnuts at least once a week is thought to mean that a group has 83% the chance of dying than a comparison group who don’t consumer walnuts.

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There are several ways that nuts could have such an effect. The unsaturated fats they contain help lower LDL (bad) cholesterol and raise HDL (good) cholesterol. One group of unsaturated fat found in walnuts, the omega-3 polyunsaturated fatty acids (PUFAs), appears to prevent the development of erratic heart rhythms. Omega-3 fatty acids (which are also found in fatty fish such as salmon and bluefish) may also prevent blood clots, much as aspirin does.In addition, research has shown that diets rich in omega-3 polyunsaturated fatty acids can significantly reduce blood low-density lipoprotein (LDL) cholesterol levels, increase the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio, and help achieve optimal fat consumption without adverse effects on total fat or energy intake ⁶, ⁷.

In one large study examining nuts and health, researchers analyzed data from over 210,000 health professionals followed up to 32 years ⁴. They found that, compared with those who never or almost never ate nuts, people who ate one ounce of nuts five or more times per week had a 14% lower risk of cardiovascular disease and a 20% lower risk of coronary heart disease during the study period. Both peanuts (technically a legume, but nutritionally similar to nuts) and walnuts were linked with lower disease risk.

In addition, other large prospective studies have consistently observed a reduction in cardiovascular disease (CVD) risk and mortality associated with increased nut consumption ⁸. Clinical trials have also have shown effects on cardiovascular disease (CVD) risk factors such as lipid profiles, vascular inflammation and blood pressure after various interventions that have included nuts, such as a Mediterranean diet ⁹. Nuts are a complex food composed of a number of nutrients and phytochemicals that may lower cardiovascular disease risk.

Among members of the nut family, walnuts have been found to be particularly promising in terms of health benefits. Compared with most other nuts, walnuts have a higher content of polyunsaturated fatty acids (PUFAs), including α-linolenic acid (ALA), which may confer additional antiatherogenic influences ¹⁰. Epidemiological studies suggest that plant-derived α-linolenic acid (ALA) may confer particular cardiovascular benefits ¹¹. According to a review of clinical trials, consumption of 2–3 servings of walnuts per day has been found to consistently decrease total cholesterol and LDL cholesterol ¹⁰. Consumption of walnuts has also been shown to improve endothelial function in individuals with hypercholesterolemia and type 2 diabetes ¹², ¹³. In addition, walnuts have been found to increase the insulin response during an oral glucose tolerance test, and to decrease levels of glycated hemoglobin (HbA1c), in individuals with polycystic ovary syndrome (PCOS) ¹⁴.

Several reviews have described possible explanations and mechanisms by which this unique fatty acid profile can beneficially affect cholesterol concentrations and other cardiovascular disease risk factors ¹⁵. Whether by simply replacing saturated fatty acids in the diet or by explicitly acting on various pathways in cardiovascular disease (CVD) development, walnuts appear to have the potential to beneficially affect cardiovascular disease risk. Feeding trials have shown cholesterol-lowering trends in walnut-enriched diets compared with control diets, as reviewed by Feldman ⁶, ¹⁶. Many qualitative reviews have suggested beneficial effects of walnuts on cholesterol concentrations ¹⁷.

Nuts are a rich source of arginine, an amino acid needed to make a molecule called nitric oxide that relaxes constricted blood vessels and eases blood flow. They also contain vitamin E, folic acid, potassium, magnesium, fiber, essential fatty acids, and phytochemicals. Because different nuts supply a different mix of nutrients, it’s a good idea to incorporate a variety of nuts into a healthy eating plan.

The high levels of antioxidants found in walnuts conferred an improvement in antioxidant status as noted by increased enzyme activity and stable oxidation of LDL (bad) cholesterol. Some inflammatory markers also improved with walnut consumption compared with other diets. Evidence for C-reactive protein reduction was inconsistent, although decreases in vascular cell adhesion molecule 1 (VCAM-1) were apparent among subjects during walnut-rich diets. Vascular cell adhesion molecule 1 (VCAM-1) is a marker for endothelial function. Overall, walnuts significantly improved lipid profiles and favorably affected a number of other factors associated with cardiovascular disease risk. There was no evidence, however, which suggests that walnut-enriched diets beneficially affected insulin resistance or blood pressure ¹⁶.

Of course, eating nuts won’t do much good if you gobble them in addition to usual snacks and meals. Furthermore, due to their high energy density, they are also a theoretical contributor to positive energy balance and weight gain, which potentially raises questions about such recommendations ¹⁸. At an average of 185 calories per ounce, a handful of walnuts a day could add 10 pounds or more in a year if you don’t cut back on something else. This weight gain would tip the scales toward heart disease, not away from it. Instead, eat nuts instead of chips or other, less healthy snacks. Or try using them instead of meat in main dishes, or as a healthful crunch in salads.

BMI and weight change

There has been some concern about recommending increased nut consumption for patients with high cholesterol concentrations because of the high fat content and supposed risk of weight gain. Multiple authors have reviewed this topic and conclude that short-term intervention data do not suggest a significant weight gain and to the contrary, sometimes indicate weight loss with increased nut consumption ¹⁹, ²⁰. Of the studies identified in the literature review, none reported significant weight change while on a walnut-based diet intervention. The 4 studies reporting BMI (body mass index) change ²¹ and the 8 studies reporting weight change ²², ²³, ²⁴, ²⁵, ²⁶, ²⁷ outcomes actually observed slight nonsignificant decreases from baseline. Results are mixed when compared with the control diets in a meta-analysis, producing an overall null difference between them ¹⁷. Importantly, weight gain did not occur during short-term dietary interventions with walnuts.

Walnuts nutrition facts

The walnut is nutrient-dense with protein and essential fatty acids. Walnuts without shells are 4% water, 15% protein, 65% fat, and 14% carbohydrates, including 7% dietary fiber (see Table 1).

In a 100-gram serving, walnuts provide 654 kcal and contain 15.2 g protein, 65.2 g fat and 6.7 g dietary fiber. Walnut is also has rich content (more than 19% of the Daily Value or DV) of several dietary minerals, particularly manganese at 163% DV, and B vitamins (see Table 1).

While English walnuts are the most commonly consumed, their nutrient density and profile are generally similar to those of black walnuts.

Unlike most nuts that are high in monounsaturated fatty acids, walnut oil is composed largely of polyunsaturated omega-3 fatty acids ~ 47.2 g (72% of total fats), particularly alpha-linolenic acid (14%) and linoleic acid (58%), although it does contain oleic acid as 13% of total fats ²⁸.

Table 1. Walnuts (English) nutrition facts

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Table 2. Walnuts (black, dried) nutrition facts

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Table 3. Walnuts (glazed) nutrition facts

[Source ²⁹] References

1. http://aic.ucdavis.edu/profiles/Walnut-2006.pdf
2. http://www.tis-gdv.de/tis_e/ware/nuesse/walnuss/walnuss.htm
3. http://www.fao.org/docrep/W9474T/W9474T06.HTM
4. Marta Guasch-Ferré, Xiaoran Liu, Vasanti S. Malik, Qi Sun, Walter C. Willett, JoAnn E. Manson, Kathryn M. Rexrode, Yanping Li, Frank B. Hu and Shilpa N. Bhupathiraju. Nut Consumption and Risk of Cardiovascular Disease. Journal of the American College of Cardiology. Nov 2017, 70 (20) 2519-2532. Journal of the American College of Cardiology Nov 2017, 70 (20) 2519-2532; DOI: 10.1016/j.jacc.2017.09.035 http://www.onlinejacc.org/content/70/20/2519
5. Qualified Health Claims: Letter of Enforcement Discretion – Walnuts and Coronary Heart Disease (Docket No 02P-0292). https://www.fda.gov/Food/IngredientsPackagingLabeling/LabelingNutrition/ucm072910.htm
6. The scientific evidence for a beneficial health relationship between walnuts and coronary heart disease. Feldman EB. J Nutr. 2002 May; 132(5):1062S-1101S. http://jn.nutrition.org/content/132/5/1062S.long
7. Including walnuts in a low-fat/modified-fat diet improves HDL cholesterol-to-total cholesterol ratios in patients with type 2 diabetes. Tapsell LC, Gillen LJ, Patch CS, Batterham M, Owen A, Baré M, Kennedy M. Diabetes Care. 2004 Dec; 27(12):2777-83. http://care.diabetesjournals.org/content/27/12/2777.long
8. The effects of nuts on coronary heart disease risk. Kris-Etherton PM, Zhao G, Binkoski AE, Coval SM, Etherton TD. Nutr Rev. 2001 Apr; 59(4):103-11. https://www.ncbi.nlm.nih.gov/pubmed/11368503/
9. Effect of a traditional Mediterranean diet on lipoprotein oxidation: a randomized controlled trial. Fitó M, Guxens M, Corella D, Sáez G, Estruch R, de la Torre R, Francés F, Cabezas C, López-Sabater Mdel C, Marrugat J, García-Arellano A, Arós F, Ruiz-Gutierrez V, Ros E, Salas-Salvadó J, Fiol M, Solá R, Covas MI, PREDIMED Study Investigators. Arch Intern Med. 2007 Jun 11; 167(11):1195-203. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/486851
10. Feldman EB. The scientific evidence for a beneficial health relationship between walnuts and coronary heart disease. J Nutr 2002;132:1062S–101S. http://jn.nutrition.org/content/132/5/1062S.long
11. Damasceno NR, Pérez-Heras A, Serra M et al. Crossover study of diets enriched with virgin olive oil, walnuts or almonds. Effects on lipids and other cardiovascular risk markers. Nutr Metab Cardiovasc Dis 2011;21:S14–20. http://www.nmcd-journal.com/article/S0939-4753(10)00297-8/fulltext
12. Ros E, Núñez I, Pérez-Heras A et al. A walnut diet improves endothelial function in hypercholesterolemic subjects: a randomized crossover trial. Circulation 2004;109:1609–14. http://circ.ahajournals.org/content/109/13/1609.long
13. Ma Y, Njike VY, Millet J et al. Effects of walnut consumption on endothelial function in type 2 diabetic subjects: a randomized controlled crossover trial. Diabetes Care 2010;33:227–32. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809254/
14. Brennan AM, Sweeney LL, Liu X et al. Walnut consumption increases satiation but has no effect on insulin resistance or the metabolic profile over a 4-day period. Obesity (Silver Spring) 2010;18:1176–82. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998344/
15. Fatty acid composition of nuts–implications for cardiovascular health. Ros E, Mataix J. Br J Nutr. 2006 Nov; 96 Suppl 2:S29-35. https://www.ncbi.nlm.nih.gov/pubmed/17125530/
16. Njike VY, Ayettey R, Petraro P, Treu JA, Katz DL. Walnut ingestion in adults at risk for diabetes: effects on body composition, diet quality, and cardiac risk measures. BMJ Open Diabetes Research & Care. 2015;3(1):e000115. doi:10.1136/bmjdrc-2015-000115. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679815/
17. Banel DK, Hu FB. Effects of walnut consumption on blood lipids and other cardiovascular risk factors: a meta-analysis and systematic review. The American Journal of Clinical Nutrition. 2009;90(1):56-63. doi:10.3945/ajcn.2009.27457. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696995/
18. Mattes RD, Dreher ML. Nuts and healthy body weight maintenance mechanisms. Asia Pac J Clin Nutr 2010;19:137–41. https://www.ncbi.nlm.nih.gov/pubmed/20199999
19. Sabaté J, Cordero-Macintyre Z, Siapco G, Torabian S, Haddad E. Does regular walnut consumption lead to weight gain? Br J Nutr 2005;94:859–64. https://www.ncbi.nlm.nih.gov/pubmed/16277792
20. García-Lorda P, Megias Rangil I, Salas-Salvadó J. Nut consumption, body weight and insulin resistance. Eur J Clin Nutr 2003;57(suppl 1):S8–11. https://www.ncbi.nlm.nih.gov/pubmed/12947444
21. Canales A, Benedí J, Nus M, Librelotto J, Sánchez-Montero JM, Sánchez-Muniz FJ. Effect of walnut-enriched restructured meat in the antioxidant status of overweight/obese senior subjects with at least one extra CHD-risk factor. J Am Coll Nutr 2007;26:225–32. https://www.ncbi.nlm.nih.gov/pubmed/17634167
22. Almario RU, Vonghavaravat V, Wong R, Kasim-Karakas SE. Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia. Am J Clin Nutr 2001;74:72–9
23. Zambón D, Sabaté J, Muñoz S, et al. Substituting walnuts for monounsaturated fat improves the serum lipid profile of hypercholesterolemic men and women. A randomized crossover trial. Ann Intern Med 2000;132:538–46
24. Spaccarotella KJ, Kris-Etherton PM, Stone WL, et al. The effect of walnut intake on factors related to prostate and vascular health in older men. Nutr J 2008;7:13.
25. Ros E, Núñez I, Pérez-Heras A, et al. A walnut diet improves endothelial function in hypercholesterolemic subjects: a randomized crossover trial. Circulation 2004;109:1609–14
26. Mukuddem-Petersen J, Stonehouse Oosthuizen W, Jerling JC, Hanekom SM, White Z. Effects of a high walnut and high cashew nut diet on selected markers of the metabolic syndrome: a controlled feeding trial. Br J Nutr 2007;97:1144–53
27. Tapsell LC, Gillen LJ, Patch CS, et al. Including walnuts in a low-fat/modified-fat diet improves HDL cholesterol-to-total cholesterol ratios in patients with type 2 diabetes. Diabetes Care 2004;27:2777–83
28. Fatty acid profiles, tocopherol contents, and antioxidant activities of heartnut (Juglans ailanthifolia Var. cordiformis) and Persian walnut (Juglans regia L.). Li L, Tsao R, Yang R, Kramer JK, Hernandez M. J Agric Food Chem. 2007 Feb 21; 55(4):1164-9. http://pubs.acs.org/doi/abs/10.1021/jf062322d
29. United States Department of Agriculture Agricultural Research Service. National Nutrient Database for Standard Reference Release 28. https://ndb.nal.usda.gov/ndb/search/list